Optic atrophy 1 is an A-kinase anchoring protein on lipid droplets that mediates adrenergic control of lipolysis

• Published in: The EMBO journal Vol. 30; no. 21; pp. 4371 - 4386
• Main Authors: Pidoux, Guillaume, Witczak, Oliwia, Jarnæss, Elisabeth, Myrvold, Linda, Urlaub, Henning, Stokka, Anne Jorunn, Küntziger, Thomas, Taskén, Kjetil
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 02.11.2011; Nature Publishing Group UK; Springer Nature B.V; EMBO Press; Nature Publishing Group
• Subjects: 3T3-L1 Cells; A Kinase Anchor Proteins - genetics; A Kinase Anchor Proteins - metabolism; A Kinase Anchor Proteins - physiology; Adrenergic beta-Agonists - pharmacology; Amino Acid Sequence; Animals; cAMP; Carrier Proteins - metabolism; cell signalling; Cellular Biology; Cyclic AMP-Dependent Protein Kinases - metabolism; EMBO20; EMBO21; Fatty acids; GTP Phosphohydrolases - antagonists & inhibitors; GTP Phosphohydrolases - genetics; GTP Phosphohydrolases - metabolism; GTP Phosphohydrolases - physiology; Isoproterenol - pharmacology; Kinases; Life Sciences; Lipid Metabolism - drug effects; Lipid Metabolism - genetics; Lipids; lipolysis; Lipolysis - drug effects; Lipolysis - genetics; Mice; Models, Biological; Molecular biology; OPA1; Peptides; perilipin; Perilipin-1; Phosphoproteins - metabolism; Proteins; Receptors, Adrenergic, beta - metabolism; Receptors, Adrenergic, beta - physiology; RNA, Small Interfering - pharmacology; Signal transduction; Subcellular Processes; perilipin; OPA1; cAMP; lipolysis; cell signalling; cellular metabolism Keywords: cAMP; Subject Categories: membranes & transport

Adrenergic stimulation of adipocytes yields a cAMP signal that activates protein kinase A (PKA). PKA phosphorylates perilipin, a protein localized on the surface of lipid droplets that serves as a gatekeeper to regulate access of lipases converting stored triglycerides to free fatty acids and glycer...