Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system

• Published in: Journal of leukocyte biology Vol. 84; no. 4; pp. 932 - 939
• Main Authors: Dilger, Ryan N., Johnson, Rodney W.
• Format: Journal Article
• Language: English
• Published: United States Society for Leukocyte Biology 01.10.2008; The Society for Leukocyte Biology
• Subjects: Adult; Aged; Aging - drug effects; Aging - immunology; Aging - physiology; Animals; Brain - drug effects; Brain - immunology; Brain - physiopathology; cytokine; Humans; inflammation; Inflammation - immunology; Inflammation - physiopathology; Lipopolysaccharides - pharmacology; microglia; Microglia - drug effects; Microglia - immunology; Microglia - physiology; Models, Animal; Models, Biological; sickness behavior

Recent studies suggest that activation of the peripheral immune system elicits a discordant central (i.e., in the brain) inflammatory response in aged but otherwise healthy subjects compared with younger cohorts. A fundamental difference in the reactive state of microglial cells in the aged brain ha...