Inhibition of Food Intake in Obese Subjects by Peptide YY3–36

• Published in: The New England journal of medicine Vol. 349; no. 10; pp. 941 - 948
• Main Authors: Batterham, Rachel L, Cohen, Mark A, Ellis, Sandra M, Le Roux, Carel W, Withers, Dominic J, Frost, Gary S, Ghatei, Mohammad A, Bloom, Stephen R
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 04.09.2003
• Subjects: Appetite - drug effects; Biological and medical sciences; Cross-Over Studies; Double-Blind Method; Eating - drug effects; Female; Ghrelin; Humans; Insulin - blood; Leptin - blood; Male; Medical sciences; Metabolic diseases; Obesity; Obesity - blood; Obesity - drug therapy; Peptide Fragments; Peptide Hormones - blood; Peptide YY - pharmacology; Peptide YY - therapeutic use; Human; Obesity; Gastrointestinal hormone; Treatment; Food intake; Treatment efficiency; Peptide hormone; Nutrition disorder; Inhibition; YY peptide; Nutritional status

The gut hormone peptide YY 3–36 (PYY) has been shown to decrease appetite and caloric intake in subjects of normal weight, but it was not known whether obese people are resistant to PYY, as they are to leptin. In this double-blind, controlled, crossover trial, PYY levels were lower in obese subjects...