Induction of autophagy and autophagy‐dependent apoptosis in diffuse large B‐cell lymphoma by a new antimalarial artemisinin derivative, SM1044

• Published in: Cancer medicine (Malden, MA) Vol. 7; no. 2; pp. 380 - 396
• Main Authors: Cheng, Chunyan, Wang, Tao, Song, Zhiqun, Peng, Lijun, Gao, Mengqing, Hermine, Olivier, Rousseaux, Sophie, Khochbin, Saadi, Mi, Jian‐Qing, Wang, Jin
• Format: Journal Article
• Language: English
• Published: United States Wiley 01.02.2018; John Wiley and Sons Inc
• Subjects: Animals; Antimalarials - pharmacology; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; artemisinin derivative; Artemisinins - pharmacology; Autophagy; Biochemistry, Molecular Biology; Cancer Biology; Cell Proliferation - drug effects; DLBCL; Female; Humans; Life Sciences; Lymphoma, Large B-Cell, Diffuse - drug therapy; Lymphoma, Large B-Cell, Diffuse - pathology; Mice; Mice, Nude; Molecular biology; Original Research; Survivin; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; artemisinin derivative; DLBCL; autophagy; Survivin; Apoptosis

Diffuse large B‐cell lymphoma (DLBCL) is the most common form of non‐Hodgkin's lymphoma. R‐CHOP is currently the standard therapy for DLBCL, but the prognosis of refractory or recurrent patients remains poor. In this study, we synthesized a new water‐soluble antimalarial drug artemisinin deriva...