Human Immunodeficiency Virus (HIV) Infection of Human Macrophages Is Increased by Dopamine: A Bridge between HIV-Associated Neurologic Disorders and Drug Abuse

• Published in: The American journal of pathology Vol. 175; no. 3; pp. 1148 - 1159
• Main Authors: Gaskill, Peter J, Calderon, Tina M, Luers, Aimee J, Eugenin, Eliseo A, Javitch, Jonathan A, Berman, Joan W
• Format: Journal Article
• Language: English
• Published: Bethesda, MD ASIP 01.09.2009; American Society for Investigative Pathology
• Subjects: Addictive behaviors; Adult and adolescent clinical studies; Biological and medical sciences; Cells, Cultured; Central Nervous System - metabolism; Dopamine - metabolism; Dopamine - pharmacology; Dopamine Agents - metabolism; Dopamine Agents - pharmacology; Drug addiction; HIV - drug effects; HIV - physiology; HIV Infections - etiology; HIV Infections - immunology; HIV Infections - metabolism; HIV Infections - virology; Human immunodeficiency virus; Human viral diseases; Humans; Infectious diseases; Investigative techniques, diagnostic techniques (general aspects); Macrophage Activation; Macrophages - metabolism; Macrophages - virology; Medical sciences; Mitogen-Activated Protein Kinase 3 - metabolism; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Phosphorylation; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Receptors, Dopamine D1 - agonists; Receptors, Dopamine D1 - metabolism; Receptors, Dopamine D2 - agonists; Receptors, Dopamine D2 - metabolism; Regular; Signal Transduction; Substance-Related Disorders - complications; Substance-Related Disorders - metabolism; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Virus Replication - drug effects; Human; Immunopathology; Drug addiction; Dopamine; Retroviridae; AIDS; Substance abuse; Catecholamine; Immune deficiency; Lentivirus; Infection; Virus; Bridges; Anatomic pathology; Addiction; Viral disease; Neurotransmitter; Complication; Human immunodeficiency virus; Macrophage

The prevalence of human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) that result from HIV infection of the central nervous system is increasing. Macrophages, the primary target for HIV within the central nervous system, play a central role in HIV-induced neuropathogenesis....