Saccular Aneurysms on Straight and Curved Vessels Are Subject to Different Hemodynamics: Implications of Intravascular Stenting

• Published in: American Journal of Neuroradiology Vol. 27; no. 9; pp. 1861 - 1865
• Main Authors: Meng, H, Wang, Z, Kim, M, Ecker, R.D, Hopkins, L.N
• Format: Journal Article
• Language: English
• Published: Oak Brook, IL Am Soc Neuroradiology 01.10.2006; American Society of Neuroradiology
• Subjects: Animals; Biological and medical sciences; Blood Circulation - physiology; Blood Flow Velocity - physiology; Computer Simulation; Disease Models, Animal; Dogs; Dye Dilution Technique; Equipment Design; In Vitro Techniques; Interventional; Intracranial Aneurysm - physiopathology; Intracranial Aneurysm - therapy; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Miscellaneous; Models, Cardiovascular; Nervous system; Neuropharmacology; Pharmacology. Drug treatments; Rabbits; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Recurrence; Stents; Vascular disease; Human; Nervous system diseases; Radiodiagnosis; Aneurysm; Cardiovascular disease; Hemodynamics
• ISSN: 0195-6108; 1936-959X

Our aim was to examine hemodynamic implications of intravascular stenting in the canine venous pouch (sidewall or straight-vessel) and rabbit elastase (curved-vessel) aneurysm models. Flow dynamics in stented (Wallstent) and nonstented versions were studied by using computational fluid dynamics simulations and in vitro flow visualization, with a focus on stent placement effects on aneurysmal flow stagnancy and flow impingement. Results show that sidewall and curved aneurysm models have fundamentally different hemodynamics (shear-driven versus inertia-driven) and thus stent placement outcomes.