Cytokine influence on simian immunodeficiency virus replication within primary macrophages. TNF-alpha, but not GMCSF, enhances viral replication on a per-cell basis

• Published in: The American journal of pathology Vol. 139; no. 4; pp. 877 - 887
• Main Authors: Walsh, DG, Horvath, CJ, Hansen-Moosa, A, MacKey, JJ, Sehgal, PK, Daniel, MD, Desrosiers, RC, Ringler, DJ
• Format: Journal Article
• Language: English
• Published: Bethesda, MD ASIP 01.10.1991; American Society for Investigative Pathology
• Subjects: AIDS/HIV; Animals; Biological and medical sciences; Bronchoalveolar Lavage Fluid - cytology; Cells, Cultured; Cytokines - pharmacology; Cytoplasm - drug effects; Cytoplasm - microbiology; Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology; Immunopathology; Interferon-gamma - pharmacology; Interleukin-6 - pharmacology; Macaca mulatta; Macrophages - microbiology; Medical sciences; Simian Immunodeficiency Virus - physiology; Tumor Necrosis Factor-alpha - pharmacology; Up-Regulation - drug effects; Virus Replication - drug effects; Cell culture; Immunopathology; Pathophysiology; Cytokine; Retroviridae; Animal origin; In vitro; Biological activity; Infection; Virus; Viral disease; Lentivirinae; Replication; Models; Human immunodeficiency virus; Simian immunodeficiency virus; Macrophage

The control of HIV-1 or SIV replication within macrophages is probably influenced by a variety of viral and cellular factors. Of the cellular factors, the authors have studied cytokine influence on SIV replication in vitro utilizing simian alveolar macrophages and uncloned SIVmacMTV, a macrophage-tr...