The Vat‐AIEC protease promotes crossing of the intestinal mucus layer by Crohn's disease‐associated Escherichia coli

• Published in: Cellular microbiology Vol. 18; no. 5; pp. 617 - 631
• Main Authors: Gibold, Lucie, Garenaux, Estelle, Dalmasso, Guillaume, Gallucci, Camille, Cia, David, Mottet‐Auselo, Benoit, Faïs, Tiphanie, Darfeuille‐Michaud, Arlette, Nguyen, Hang Thi Thu, Barnich, Nicolas, Bonnet, Richard, Delmas, Julien
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2016; Wiley
• Subjects: AIEC; Animals; Bacterial Adhesion - genetics; Bacterial Toxins - genetics; Bacterial Toxins - metabolism; Bacteriology; Colonization; Crohn Disease - genetics; Crohn Disease - microbiology; Crohn Disease - pathology; Crohn's disease; E coli; Epithelial Cells - microbiology; Escherichia coli; Escherichia coli - genetics; Escherichia coli - pathogenicity; Escherichia coli Infections - genetics; Escherichia coli Infections - microbiology; Escherichia coli Infections - pathology; Escherichia coli Proteins - genetics; Escherichia coli Proteins - metabolism; Gastrointestinal Microbiome - genetics; Genetic factors; Human health and pathology; Humans; Ileum - microbiology; Ileum - pathology; Infectious diseases; Intestinal Mucosa - microbiology; Life Sciences; Mice; Microbiology and Parasitology; mucinase; Mucins; Mucus - microbiology; serine protease; AIEC; Crohn's disease; mucins; serine protease; Escherichia coli; mucinase

Summary The aetiology of Crohn's disease (CD) involves disorders in host genetic factors and intestinal microbiota. Adherent‐invasive Escherichia coli (AIEC) are receiving increased attention because in studies of mucosa‐associated microbiota, they are more prevalent in CD patients than in heal...