Intracellular Ca2+ Handling and Vulnerability to Ventricular Fibrillation in Spontaneously Hypertensive Rats

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 30; no. 3; pp. 461 - 467
• Main Authors: Zaugg, Christian E, Wu, Shao T, Lee, Randall J, Wikman-Coffelt, Joan, Parmley, William W
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.09.1997; Hagerstown, MD Lippincott
• Subjects: Animals; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Calcium - metabolism; Cardiac Pacing, Artificial - methods; Cardiology. Vascular system; Cardiomegaly - complications; Differential Threshold; Disease Susceptibility; Experimental diseases; Hypertension - complications; Hypertension - metabolism; In Vitro Techniques; Intracellular Membranes - metabolism; Male; Medical sciences; Rats; Rats, Inbred SHR - physiology; Rats, Inbred WKY; Stress, Mechanical; Ventricular Fibrillation - etiology; Heart; Hypertension; Arrhythmia; Calcium; Rat; Rodentia; Cardiovascular disease; Hereditary; Excitability disorder; Stress; Ventricular fibrillation; Vertebrata; Mammalia; Heart disease; Animal; Risk factor; Intracellular; Hypertrophy

Spontaneously hypertensive rats (SHR) with ventricular hypertrophy show an increased vulnerability for the development of potentially lethal ventricular arrhythmias such as ventricular fibrillation (VF). The mechanisms of this increased vulnerability are not fully understood but may be related to ab...