NaHCO3-induced alkalosis reduces the phosphocreatine slow component during heavy-intensity forearm exercise

• Published in: Journal of applied physiology (1985) Vol. 99; no. 5; pp. 1668 - 1675
• Main Authors: Forbes, S. C, Raymer, G. H, Kowalchuk, J. M, Marsh, G. D
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.11.2005; American Physiological Society
• Subjects: Acid-Base Equilibrium - drug effects; Acid-Base Equilibrium - physiology; Acidosis, Lactic - metabolism; Acidosis, Lactic - physiopathology; Adenosine Diphosphate - metabolism; Adenosine Triphosphate - metabolism; Adult; Alkalosis - metabolism; Alkalosis - physiopathology; Biological and medical sciences; Exercise; Exercise - physiology; Forearm - physiology; Fundamental and applied biological sciences. Psychology; Humans; Lactic Acid - metabolism; Male; Muscle, Skeletal - physiology; Muscular system; NMR; Nuclear magnetic resonance; Oxidation; Oxidative Phosphorylation; Phosphocreatine - metabolism; Protons; Sodium Bicarbonate - administration & dosage; Physical exercise; Intensity; Magnetic resonance; muscle energetics; Phosphorus; Acid base balance disorder; Phosphocreatine; Striated muscle; Hydrogencarbonates; Metabolic disorder; Vertebrata; Forearm; Mammalia; Sodium; acid-base status; phosphorus-31 magnetic resonance spectroscopy; sodium bicarbonate; Alkalosis

1 School of Kinesiology, 2 Department of Medical Biophysics, and 3 Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada Submitted 25 October 2004 ; accepted in final form 4 July 2005 During heavy-intensity exercise, the mechanisms responsible for the continued...