Probing the Effects of Stress Mediators on the Human Hair Follicle: Substance P Holds Central Position

• Published in: The American journal of pathology Vol. 171; no. 6; pp. 1872 - 1886
• Main Authors: Peters, Eva M.J, Liotiri, Sofia, Bodo, Eniko, Hagen, Evelin, Biro, Tamas, Arck, Petra C, Paus, Ralf
• Format: Journal Article
• Language: English
• Published: Bethesda, MD ASIP 01.12.2007; American Society for Investigative Pathology
• Subjects: Biological and medical sciences; Biological Assay; Cell Degranulation; Hair Follicle - drug effects; Hair Follicle - growth & development; Hair Follicle - metabolism; Histocompatibility Antigens Class I - metabolism; Humans; In Vitro Techniques; Investigative techniques, diagnostic techniques (general aspects); Mast Cells - drug effects; Mast Cells - physiology; Medical sciences; Nerve Growth Factor - metabolism; Nerve Tissue Proteins - metabolism; Neurokinin-1 Receptor Antagonists; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Receptor, trkA - antagonists & inhibitors; Receptor, trkA - metabolism; Receptors, Nerve Growth Factor - metabolism; Receptors, Neurokinin-1 - metabolism; Regular; Scalp - drug effects; Scalp - metabolism; Stress, Physiological - metabolism; Substance P - pharmacology; Up-Regulation; Human; Anatomic pathology; Position; Substance P; Hair follicle; Mediator; Neuropeptide; Tachykinin; Stress

Stress alters murine hair growth, depending on substance P-mediated neurogenic inflammation and nerve growth factor (NGF), a key modulator of hair growth termination (catagen induction). Whether this is of any relevance in human hair follicles (HFs) is completely unclear. Therefore, we have investig...