GPR88 in A2A receptor‐expressing neurons modulates locomotor response to dopamine agonists but not sensorimotor gating

• Published in: The European journal of neuroscience Vol. 46; no. 4; pp. 2026 - 2034
• Main Authors: Meirsman, A. C., Kerchove d'Exaerde, A., Kieffer, B. L., Ouagazzal, A.‐M.
• Format: Journal Article
• Language: English
• Published: Chichester Wiley Subscription Services, Inc 01.08.2017
• Subjects: Amphetamines; Auditory pathways; Channel gating; cross‐modal PPI; D2R‐medium spiny neurons; Dopamine; Dopamine D1 receptors; Dopamine D2 receptors; GAP detection; Hyperactivity; Hypersensitivity; Information processing; Life Sciences; Locomotion; Locomotor activity; Mental disorders; Neostriatum; Neurons and Cognition; Psychosis; Quinpirole; Rodents; Schizophrenia; Sensorimotor gating; Spiny neurons; striatum; Visual pathways; D2R-medium spiny neurons; schizophrenia; GAP detection; striatum; cross-modal PPI

The orphan receptor, GPR88, is emerging as a key player in the pathophysiology of several neuropsychiatric diseases, including psychotic disorders. Knockout (KO) mice lacking GPR88 throughout the brain exhibit many abnormalities relevant to schizophrenia including locomotor hyperactivity, behavioura...