X inactivation in human testicular tumors. XIST expression and androgen receptor methylation status

• Published in: The American journal of pathology Vol. 151; no. 2; pp. 581 - 590
• Main Authors: Looijenga, LH, Gillis, AJ, van Gurp, RJ, Verkerk, AJ, Oosterhuis, JW
• Format: Journal Article
• Language: English
• Published: Bethesda, MD ASIP 01.08.1997; American Society for Investigative Pathology
• Subjects: Adult; Biological and medical sciences; Carcinoma in Situ - genetics; Carcinoma in Situ - metabolism; Carcinoma in Situ - pathology; Female; Gynecology. Andrology. Obstetrics; Humans; Male; Male genital diseases; Medical sciences; Methylation; Receptors, Androgen - metabolism; RNA, Long Noncoding; RNA, Untranslated; Testicular Neoplasms - genetics; Testicular Neoplasms - metabolism; Testicular Neoplasms - pathology; Transcription Factors - biosynthesis; Transcription Factors - genetics; Tumors; X Chromosome; Human; Androgen; In situ; Malignant tumor; Hybridization; Inactivation; Testicle; Polymerase chain reaction; Germ cell tumor; X-Chromosome; Molecular biology; Sex steroid hormone; Methylation; Male genital diseases; Testicular diseases; Quantitative analysis; Hormonal receptor

In female mammalian cells, inactivation of one of the X chromosomes compensates the increased dosage of X-linked genes as compared with their male counterparts. This process is initiated by the X-inactive specific transcripts of the xist/XIST gene in cis, resulting in methylation of specific sites o...