Long-term outcomes after stenting of bifurcation lesions with the crush technique : Predictors of an adverse outcome

• Published in: Journal of the American College of Cardiology Vol. 47; no. 10; pp. 1949 - 1958
• Main Authors: HOYE, Angela, IAKOVOU, Ioannis, CHIEFFO, Alaide, CARLINO, Mauro, CORVAJA, Nicola, AOKI, Jiro, GRANILLO, Gaston A. Rodriguez, VALGIMIGLI, Marco, SIANOS, Georgios, VAN DER GIESSEN, Willem J, DE FEYTER, Pim J, VAN DOMBURG, Ron T, LEI GE, SERRUYS, Patrick W, COLOMBO, Antonio, VAN MIEGHEM, Carlos A. G, ONG, Andrew T. L, COSGRAVE, John, SANGIORGI, Giuseppe M, AIROLDI, Flavio, MONTORFANO, Matteo, MICHEV, Iassen
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Science 16.05.2006; Elsevier Limited
• Subjects: Acute coronary syndromes; Angina Pectoris - etiology; Angina Pectoris - therapy; Angioplasty; Angioplasty, Balloon, Coronary; Biological and medical sciences; Blood Vessel Prosthesis Implantation - adverse effects; Cardiology; Cardiology. Vascular system; Cardiovascular Agents - administration & dosage; Coronary Angiography; Coronary Restenosis - prevention & control; Coronary Stenosis - complications; Coronary Stenosis - therapy; Coronary Thrombosis - etiology; Delayed-Action Preparations; Female; Heart attacks; Humans; Kinases; Male; Medical imaging; Medical sciences; Middle Aged; Paclitaxel - administration & dosage; Postoperative Complications; Prognosis; Sirolimus - administration & dosage; Stents; Stents - adverse effects; Thrombosis; Time Factors; Treatment Outcome; Prognosis; Predictor; Prediction; Bifurcation; Instrumentation therapy; Instrumental dilatation; Long term; Phlebology; Stent; Complication; Evolution; Circulatory system; Lesion; Technique; Cardiology; Predictive factor
• DOI: 10.1016/j.jacc.2005.11.083
• ISSN: 0735-1097

The purpose of this study was to evaluate predictors of an adverse outcome after "crush" bifurcation stenting. The "crush" technique is a recently introduced strategy with limited data regarding long-term outcomes. We identified 231 consecutive patients treated with drug-eluting stent implantation with the "crush" technique for 241 de novo bifurcation lesions. Clinical follow-up was obtained in 99.6%. The in-hospital major adverse cardiac event (MACE) rate was 5.2%. At 9 months, 10 (4.3%) patients had an event consistent with possible post-procedural stent thrombosis. Survival free of target lesion revascularization (TLR) was 90.3%; the only independent predictor of TLR was left main stem (LMS) therapy (odds ratio [OR] 4.97; 95% confidence interval [CI] 2.00 to 12.37, p = 0.001). Survival free of MACE was 83.5% and independent predictors of MACE were LMS therapy (OR 3.79; 95% CI 1.76 to 8.14, p = 0.001) and treatment of patients with multivessel disease (OR 4.21; 95% CI 0.95 to 18.56, p = 0.058). Angiographic follow-up was obtained in 77% of lesions at 8.3 +/- 3.7 months. The mean late loss of the main vessel and side branch were 0.30 +/- 0.64 mm and 0.41 +/- 0.67 mm, respectively, with binary restenosis rates of 9.1% and 25.3%. Kissing balloon post-dilation significantly reduced the side branch late lumen loss (0.24 +/- 0.50 mm vs. 0.58 +/- 0.77 mm, p < 0.001). The crush technique of bifurcation stenting with drug-eluting stents is associated with favorable outcomes for most lesions; however, efficacy appears significantly reduced in LMS bifurcations, and further research is needed before the technique can be routinely recommended in this group. Furthermore, the incidence of possible stent thrombosis is of concern and requires further investigation. Kissing balloon post-dilatation is mandatory to reduce side branch restenosis.