Renal Clearance of B-Type Natriuretic Peptide and Amino Terminal Pro-B-Type Natriuretic Peptide : A Mechanistic Study in Hypertensive Subjects

• Published in: Journal of the American College of Cardiology Vol. 53; no. 10; pp. 884 - 890
• Main Authors: VAN KIMMENADE, Roland R. J, JANUZZI, James L, BAKKER, Jaap A, HOUBEN, Alphonse J, RENNENBERG, Roger, KROON, Abraham A, CRIJNS, Harry J. G. M, VAN DIEIJEN-VISSER, Marja P, DE LEEUW, Peter W, PINTO, Yigal M
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier 10.03.2009; Elsevier Limited
• Subjects: Arterial hypertension. Arterial hypotension; Biological and medical sciences; Biomarkers - metabolism; Blood and lymphatic vessels; Body mass index; Cardiology; Cardiology. Vascular system; Disease; Female; Glomerular Filtration Rate; Heart failure; Humans; Hypertension - blood; Hypertension - physiopathology; Kidney - metabolism; Kidney - physiopathology; Male; Medical sciences; Middle Aged; Natriuretic Peptide, Brain - blood; Natriuretic Peptide, Brain - metabolism; Peptide Fragments - blood; Peptide Fragments - metabolism; Peptides; Prospective Studies; Radiography; Renal Artery - diagnostic imaging; Renal Plasma Flow; Rodents; Studies; Veins & arteries; Human; Hypertension; Brain natriuretic peptide; Cardiovascular disease; Circulatory system; Clearance; Cardiology; Kidney; Aminoacid sequence

This study sought to compare the renal clearance mechanisms of B-type natriuretic peptide (BNP) and amino terminal pro-B-type natriuretic peptide (NT-proBNP). The small molecular weight proteins (SMWPs) BNP and NT-proBNP both inversely correlate with glomerular filtration rate (GFR). Whether this as...