High-throughput molecular analysis of urine sediment for the detection of bladder cancer by high-density single-nucleotide polymorphism array

• Published in: Cancer research (Chicago, Ill.) Vol. 63; no. 18; pp. 5723 - 5726
• Main Authors: MOHAMMAD OBAIDUL HOQUE, LEE, Juna, BEGUM, Shahnaz, YAMASHITA, Keishi, ENGLES, James M, SCHOENBERG, Mark, WESTRA, William H, SIDRANSKY, David
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.09.2003
• Subjects: Adult; Aged; Allelic Imbalance; Biological and medical sciences; Carcinoma, Transitional Cell - genetics; Carcinoma, Transitional Cell - urine; DNA, Neoplasm - genetics; DNA, Neoplasm - urine; Female; Genomic Instability; Humans; Loss of Heterozygosity; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Polymorphism, Single Nucleotide; Tumors of the urinary system; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - urine; Urinary tract. Prostate gland; Human; Urine; Biological fluid; Urinary system disease; Methodology; Malignant tumor; Allele; Investigation method; Urinary bladder; Microsatellite DNA; DNA; Non invasive method; Loss of heterozygosity; Instability; Bladder disease; Diagnosis; Single nucleotide polymorphism; Detection
• ISSN: 0008-5472

The detection of urothelial malignancies remains challenging. The majority of patients diagnosed with bladder cancer require life-long surveillance for disease recurrence. Monitoring strategies rely predominantly on invasive endoscopic techniques, which are inconvenient and uncomfortable. Multiple i...