Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals : The EPIC-Norfolk prospective population study

• Published in: Journal of the American College of Cardiology Vol. 50; no. 2; pp. 159 - 165
• Main Authors: MEUWESE, Marijn C, STROES, Erik S. G, MATTHIJS BOEKHOLDT, S, HAZEN, Stanley L, VAN MIERT, Joram N, KUIVENHOVEN, Jan Albert, SCHAUB, Robert G, WAREHAM, Nicholas J, LUBEN, Robert, KASTELEIN, John J. P, KHAW, Kay-Tee
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Science 10.07.2007; Elsevier Limited
• Subjects: Age; Aged; Biological and medical sciences; Biomarkers - blood; Blood Pressure; Body mass index; Cardiology; Cardiology. Vascular system; Cardiovascular disease; Case-Control Studies; Cholesterol; Confidence intervals; Coronary Artery Disease - blood; Coronary heart disease; Diabetes; Female; Gender; Heart; Hospitals; Humans; Immune system; Lipids - blood; Male; Medical sciences; Middle Aged; Nutrition research; Peroxidase - blood; Prospective Studies; Ratios; Risk Factors; Studies; Triglycerides; Variables; Human; Enzyme; Cardiovascular disease; Risk; Coronary heart disease; Epidemiology; Phlebology; Prospective; Association; Peroxidases; Individual; Risk factor; Population; Serum; Level; Peroxidase; Oxidoreductases; Circulatory system; Cardiology; Public health

We evaluated whether serum myeloperoxidase (MPO) levels are associated with the risk of future development of coronary artery disease (CAD) in apparently healthy individuals. An enzyme of the innate immune system, MPO exhibits a wide array of proatherogenic effects. These include induction of oxidat...