Endothelial Function in Human Immunodeficiency Virus-Infected Antiretroviral-Naive Subjects Before and After Starting Potent Antiretroviral Therapy : The ACTG (AIDS Clinical Trials Group) Study 5152s

• Published in: Journal of the American College of Cardiology Vol. 52; no. 7; pp. 569 - 576
• Main Authors: TORRIANI, Francesca J, KOMAROW, Lauren, SQUIRES, Kathleen, STEIN, James H, PARKER, Robert A, COTTER, Bruno R, CURRIER, Judith S, DUBE, Michael P, FICHTENBAUM, Carl J, GERSCHENSON, Mariana, MITCHELL, Carol K. C, MURPHY, Robert L
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Science 12.08.2008; Elsevier Limited
• Subjects: Adenine - administration & dosage; Adenine - analogs & derivatives; Adult; Aging; Alkynes; Anti-HIV Agents - administration & dosage; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Benzoxazines - administration & dosage; Biological and medical sciences; Brachial Artery - drug effects; Brachial Artery - physiopathology; Cardiology; Cardiology. Vascular system; CD4 Lymphocyte Count; Cholesterol; Clinical trials; Cyclopropanes; Deflation; Diabetes; Drug therapy; Endothelium, Vascular - drug effects; Endothelium, Vascular - pathology; Female; HIV; HIV Infections - drug therapy; HIV Infections - physiopathology; HIV Protease Inhibitors - administration & dosage; HIV-1; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infections; Infectious diseases; Lamivudine - administration & dosage; Lopinavir; Male; Medical sciences; Organophosphonates - administration & dosage; Pharmacology. Drug treatments; Prospective Studies; Pyrimidinones - administration & dosage; Reverse Transcriptase Inhibitors - administration & dosage; Risk factors; Ritonavir - administration & dosage; Stavudine - administration & dosage; Studies; Tenofovir; Time Factors; Ultrasonic imaging; Veins & arteries; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Zidovudine - administration & dosage; Human; Immunopathology; Antiretroviral agent; AIDS; Endothelial function; Immune deficiency; Infection; Symptomatology; Treatment; Viral disease; Starting; Antiviral; Clinical trial; Circulatory system; Cardiology

This study evaluated the effects of 3 class-sparing antiretroviral therapy (ART) regimens on endothelial function in human immunodeficiency virus (HIV)-infected subjects participating in a randomized trial. Endothelial dysfunction has been observed in patients receiving ART for HIV infection. This w...