Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and Haptens : comparison with experimental data

• Published in: Cancer research (Chicago, Ill.) Vol. 52; no. 20; pp. 5838 - 5844
• Main Authors: BAXTER, L. T, YUAN, F, JAIN, R. K
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.10.1992
• Subjects: Antibodies, Neoplasm - administration & dosage; Antibodies, Neoplasm - blood; Antineoplastic agents; Binding Sites, Antibody; Biological and medical sciences; Extravasation of Diagnostic and Therapeutic Materials - metabolism; Haptens - administration & dosage; Haptens - blood; Humans; Immunotherapy; Kinetics; Mathematical Computing; Medical sciences; Models, Biological; Neoplasms - blood; Neoplasms - blood supply; Pharmacology. Drug treatments; Sensitivity and Specificity; Antineoplastic agent; Tumor associated antigen; Administration schedule; Monoclonal antibody; Radioisotope; Malignant tumor; Hapten; Target; Treatment; Immunotherapy; Blood vessel; Distribution; Mathematical model; Pharmacokinetics; Tumor cell

A mathematical model is developed to describe the concentration profiles around individual tumor blood vessels for two-step approaches to cancer treatment. The model incorporates plasma pharmacokinetics, interstitial diffusion, reversible binding between antibody and hapten and between antibody and...