Molecular genetic alterations in superficial and locally advanced human bladder cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 51; no. 19; pp. 5405 - 5409
• Main Authors: PRESTI, J. C, REUTER, V. E, GALAN, T, FAIR, W. R, CORDON-CARDO, C
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.10.1991
• Subjects: Biological and medical sciences; Blotting, Southern; carcinoma; Chromosome Deletion; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 18; Chromosomes, Human, Pair 3; DNA - analysis; Genes, Tumor Suppressor; Humans; Immunohistochemistry; Medical sciences; Neoplasm Invasiveness; Neoplasm Staging; Nephrology. Urinary tract diseases; Polymorphism, Restriction Fragment Length; restriction fragment length polymorphism; retinoblastoma; Retinoblastoma Protein - biosynthesis; Tumors of the urinary system; urinary bladder; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - metabolism; Urinary tract. Prostate gland; Chromosomal aberration; Histological grading; Human; Immunohistochemistry; Urinary system disease; Pathogenesis; Partial deletion; Abnormal E18 chromosome; Abnormal A3 chromosome; Malignant tumor; Suppressor gene; Pathology; Clinical stage; Restriction fragment length polymorphism; Urinary bladder; Abnormal chromosome; Abnormal C11 chromosome; Abnormal D13 chromosome; Abnormal E17 chromosome

We attempted to define the role of tumor suppressor genes in the pathogenesis of human bladder cancer through a combined molecular genetic and immunohistochemical approach. Thirty-four bladder tumors (1 Pis, 6 Pa, 5 P1, 3 P3a, 18 P3b, 1 P4; 8 low grade and 26 high grade tumors) have been analyzed. R...