The Pathophysiology of Heart Failure With Normal Ejection Fraction: Exercise Echocardiography Reveals Complex Abnormalities of Both Systolic and Diastolic Ventricular Function Involving Torsion, Untwist, and Longitudinal Motion

• Published in: Journal of the American College of Cardiology Vol. 54; no. 1; pp. 36 - 46
• Main Authors: YU TING TAN, WENZELBURGER, Frauke, LEE, Eveline, HEATLIE, Grant, LEYVA, Francisco, PATEL, Kiran, FRENNEAUX, Michael, SANDERSON, John E
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier 30.06.2009; Elsevier Limited
• Subjects: Aged; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular disease; Cardiovascular system; Case-Control Studies; Diastole; Echocardiography, Doppler, Color - statistics & numerical data; Exercise - physiology; Exercise Test; Female; Fractions; Heart; Heart attacks; Heart failure; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Heart Failure, Diastolic - diagnostic imaging; Heart Failure, Diastolic - physiopathology; Heart rate; Hemodynamics; Humans; Investigative techniques of hemodynamics; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Observer Variation; Oxygen Consumption; Rotation; Software; Studies; Systole; Torsion Abnormality; Ultrasonic investigative techniques; Ventricular Function; Sonography; Physical exercise; Heart failure; Motion; Cardiac performance; Echocardiography; Diastole; Pathophysiology; Cardiovascular disease; Normal; Complexes; Heart disease; Exercise tolerance test; Anomaly; Circulatory system; Hemodynamics; Cardiology; Torsion; Ejection fraction

The purpose of this study was to test the hypothesis that in heart failure with normal ejection fraction (HFNEF) exercise limitation is due to combined systolic and diastolic abnormalities, particularly involving ventricular twist and deformation (strain) leading to reduced ventricular suction, dela...