The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine

• Published in: Cancer research (Chicago, Ill.) Vol. 57; no. 13; pp. 2602 - 2605
• Main Authors: BLAY, J, WHITE, T. D, HOSKIN, D. W
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.07.1997
• Subjects: Adenosine - analysis; Animals; Biological and medical sciences; Coformycin - pharmacology; Colonic Neoplasms - chemistry; Enzyme Inhibitors - pharmacology; Extracellular Space - chemistry; Extracellular Space - drug effects; Female; Fibrosarcoma - chemistry; Host-tumor relations. Immunology. Biological markers; Humans; Lung Neoplasms - chemistry; Medical sciences; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Microdialysis; Neoplasm Transplantation; Time Factors; Tubercidin - analogs & derivatives; Tubercidin - pharmacology; Tumor Cells, Cultured; Tumors; Host tumor relation; Solid tumor; Adenosine; Purine nucleoside; Rodentia; Cellular immunity; Malignant tumor; In vivo; Extracellular fluid; Vertebrata; Immunosuppression; Experimental disease; Mammalia; Microdialysis; Mouse; Animal

The purine nucleoside adenosine (9-beta-D-ribofuranosyladenine) inhibits a number of lymphocyte functions in vitro, including the ability of activated T lymphocytes and natural killer cells to adhere to and kill tumor targets. Solid tumors, such as adenocarcinomas of the lung and colon, are frequent...