Difference in proangiogenic potential of systemic and pulmonary endothelium: role of CXCR2

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 288; no. 6; pp. L1117 - L1123
• Main Authors: Moldobaeva, Aigul, Wagner, Elizabeth M
• Format: Journal Article
• Language: English
• Published: United States 01.06.2005
• Subjects: Animals; Aorta - immunology; Aorta - metabolism; Aorta - pathology; Cathepsins - metabolism; Cell Hypoxia; Cell Movement; Cell Proliferation; Chemokine CXCL2; Chemotactic Factors - metabolism; Chemotaxis; Endothelium, Vascular - cytology; Endothelium, Vascular - immunology; Endothelium, Vascular - metabolism; Lung - cytology; Lung - immunology; Lung - metabolism; Mice; Mice, Inbred C57BL; Microcirculation - cytology; Microcirculation - immunology; Microcirculation - metabolism; Monokines - metabolism; Neovascularization, Physiologic - physiology; Pulmonary Artery - cytology; Pulmonary Artery - immunology; Pulmonary Artery - metabolism; Receptors, Cell Surface; Receptors, Interleukin-8B - metabolism

Department of Medicine, Johns Hopkins University, Baltimore, Maryland Submitted 4 October 2004 ; accepted in final form 11 February 2005 The systemic vasculature in and surrounding the lung is proangiogenic, whereas the pulmonary vasculature rarely participates in neovascularization. We studied the...