Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro

• Published in: Cancer research (Chicago, Ill.) Vol. 55; no. 9; pp. 1982 - 1988
• Main Authors: YUFANG SHI, FRANKEL, A, RADVANYI, L. G, PENN, L. Z, MILLER, R. G, MILLS, G. B
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.05.1995
• Subjects: Animals; Antineoplastic agents; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Apoptosis - drug effects; Biological and medical sciences; Cisplatin - administration & dosage; Cricetinae; Drug Synergism; Female; General aspects; Humans; Immunosuppressive Agents - administration & dosage; Leukemia, Promyelocytic, Acute - drug therapy; Leukemia, Promyelocytic, Acute - pathology; Lymphocyte Activation; Medical sciences; Mice; Ovarian Neoplasms - drug therapy; Ovarian Neoplasms - pathology; Pharmacology. Drug treatments; Polyenes - administration & dosage; Polyenes - pharmacology; Sensitivity and Specificity; Sirolimus; T-Lymphocytes - cytology; T-Lymphocytes - drug effects; Tumor Cells, Cultured - drug effects; Antineoplastic agent; Cell proliferation; Sensitivity resistance; Interleukin 2; Cell death; Immunosuppressive agent; Mechanism of action; In vitro; Macrolide; Tumor cell; Platinum II Complexes

Apoptosis can be regulated in a number of different systems by the actions of cytokines. Rapamycin has been shown to exert its effects on growth factor-induced cell proliferation, at least in part, by blocking the activation of the p70 S6 kinase and thus preventing the downstream signaling process,...