Effects of plasma treatment with purified protein A and staphylococcus aureus Cowan I on spontaneous animal neoplasms

Eleven dogs with spontaneous neoplasms were intensively treated with an immunoadsorption system consisting of a continuous flow centrifuge, Protein A-Sepharose columns, and a semi-automatic elution system. Despite consistent and substantial lowering of immunoglobulin G levels, tumor regression was n...

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Published inCancer research (Chicago, Ill.) Vol. 45; no. 3; pp. 1263 - 1269
Main Authors KLAUSNER, J. S, MILLER, W. J, ÓBRIEN, T. D, BRANDA, R. F
Format Journal Article
LanguageEnglish
Published Philadelphia, PA American Association for Cancer Research 01.03.1985
Subjects
Animals
Cat Diseases - therapy
Cats
Dog Diseases - therapy
Dogs
Female
Immunoglobulin G - analysis
Male
Neoplasms - therapy
Neoplasms - veterinary
Perfusion - methods
Plasma
Sepharose - administration & dosage
Staphylococcal Protein A - administration & dosage
Staphylococcus aureus
Staphylococcus aureus
Fissipedia
Plasma
Carnivora
Spontaneous
IgG
Immunosorption
Experimental study
Vertebrata
Mammalia
Perfusion
A-Protein
Immunotherapy
Bacteria
Micrococcales
Tumor
Micrococcaceae
Dog
Comparative study
Staphylococcus aureus
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Abstract Eleven dogs with spontaneous neoplasms were intensively treated with an immunoadsorption system consisting of a continuous flow centrifuge, Protein A-Sepharose columns, and a semi-automatic elution system. Despite consistent and substantial lowering of immunoglobulin G levels, tumor regression was noted in only one of 11 dogs. In contrast, infusion of small volumes of plasma after incubation with heat and formalin-treated Staphylococcus aureus Cowan I resulted in a tumoricidal response in five of six animals. These results suggest that tumor necrosis is probably not induced by Protein A-mediated removal of humoral "blocking" factors.
AbstractList Eleven dogs with spontaneous neoplasms were intensively treated with an immunoadsorption system consisting of a continuous flow centrifuge, Protein A-Sepharose columns, and a semi-automatic elution system. Despite consistent and substantial lowering of immunoglobulin G levels, tumor regression was noted in only one of 11 dogs. In contrast, infusion of small volumes of plasma after incubation with heat and formalin-treated Staphylococcus aureus Cowan I resulted in a tumoricidal response in five of six animals. These results suggest that tumor necrosis is probably not induced by Protein A-mediated removal of humoral "blocking" factors.
Author ÓBRIEN, T. D
BRANDA, R. F
MILLER, W. J
KLAUSNER, J. S
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Issue 3
Keywords Fissipedia
Plasma
Carnivora
Spontaneous
IgG
Immunosorption
Experimental study
Vertebrata
Mammalia
Perfusion
A-Protein
Immunotherapy
Bacteria
Micrococcales
Tumor
Micrococcaceae
Dog
Comparative study
Staphylococcus aureus
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PublicationTitle Cancer research (Chicago, Ill.)
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Snippet Eleven dogs with spontaneous neoplasms were intensively treated with an immunoadsorption system consisting of a continuous flow centrifuge, Protein A-Sepharose...
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StartPage 1263
SubjectTerms Animals
Cat Diseases - therapy
Cats
Dog Diseases - therapy
Dogs
Female
Immunoglobulin G - analysis
Male
Neoplasms - therapy
Neoplasms - veterinary
Perfusion - methods
Plasma
Sepharose - administration & dosage
Staphylococcal Protein A - administration & dosage
Staphylococcus aureus
Title Effects of plasma treatment with purified protein A and staphylococcus aureus Cowan I on spontaneous animal neoplasms
URI https://www.ncbi.nlm.nih.gov/pubmed/3971372
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Volume 45
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