Repression of protein kinase C and stimulation of cyclic AMP response elements by fumonisin, a fungal encoded toxin which is a carcinogen

• Published in: Cancer research (Chicago, Ill.) Vol. 55; no. 8; pp. 1655 - 1659
• Main Authors: CHONGXI HUANG, DICKMAN, M, HENDERSON, G, JONES, C
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.04.1995
• Subjects: Animals; Biological and medical sciences; Blotting, Western; Carcinogenesis, carcinogens and anticarcinogens; Carcinogens - toxicity; Cell Line; Cercopithecus aethiops; Cyclic AMP - metabolism; Cyclic AMP-Dependent Protein Kinases - metabolism; DNA - drug effects; DNA - metabolism; Dose-Response Relationship, Drug; Enzyme Repression; Foods and miscellaneous; Fumonisins; Fusarium moniliforme; Gene Expression - drug effects; Humans; Kidney; Medical sciences; Mycotoxins - toxicity; Protein Kinase C - biosynthesis; Restriction Mapping; Sphingosine - pharmacology; Transcription Factor AP-1 - metabolism; Transcription, Genetic - drug effects; Transfection; Tumors; Protein kinase C; Enzyme; Mycotoxin; Cyclic AMP; Gene expression; Carcinogenesis; In vitro; Kidney; Fungi; Carcinogen; Toxin; Signal transduction; Animal; Established cell line; Fungi Imperfecti; Mechanism of action; Fusarium moniliforme; Thallophyta

Fusarium moniliforme (FM) is a major fungal pathogen of corn and is involved with stalk rot disease. FM is widely spread throughout the world, including the United States. Most strains of FM produce several mycotoxins, the most prominent of which is called fumonisin. Recent epidemiological studies i...