Sensitivity to DNA damage induced by benzo(a)pyrene diol epoxide and risk of lung cancer : A case-control analysis

• Published in: Cancer research (Chicago, Ill.) Vol. 61; no. 4; pp. 1445 - 1450
• Main Authors: DONGHUI LI, FIROZI, Pervez F, WANG, Li-E, BOSKEN, Carol H, SPITZ, Margaret R, WAUN KI HONG, QINGYI WEI
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.02.2001
• Subjects: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide - toxicity; Biological and medical sciences; Carcinogens - toxicity; Case-Control Studies; DNA Adducts - metabolism; DNA Damage; DNA Repair; Epidemiology; Female; Genetic Predisposition to Disease; Humans; Lung Neoplasms - chemically induced; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Male; Medical sciences; Middle Aged; Tumors; Human; Lung disease; Genetic marker; Respiratory disease; Toxicity; Tobacco smoking; Case control study; Malignant tumor; In vitro; Bronchopulmonary; Carcinogen; Blood cell; Sensitivity; Analysis method; Test; DNA; Risk factor; Molecular epidemiology; Bronchus disease; Genetics; Lymphocyte; Molecular adduct

Levels of DNA adducts vary greatly in vivo, attributable to individual differences in enzymatic bioactivation of benzo(a)pyrene. We developed an assay to measure the levels of DNA adducts induced in vitro by benzo(a)pyrene diol epoxide (BPDE), a bioactivated form of benzo(a)pyrene. In this large mol...