Alpha adrenoceptor stimulation reduces outward currents in rat ventricular myocytes

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 250; no. 1; pp. 364 - 370
• Main Authors: RAVENS, U, WANG, X.-L, WETTWER, E
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Pharmacology and Experimental Therapeutics 01.07.1989
• Subjects: alpha -adrenergic; Animals; Biological and medical sciences; Cells, Cultured; Electric Conductivity; Fundamental and applied biological sciences. Psychology; Heart; Heart - physiology; Heart Ventricles - drug effects; Kinetics; Membrane Potentials - drug effects; Myocardial Contraction - drug effects; myocytes; norepinephrine; Norepinephrine - pharmacology; Phentolamine - pharmacology; Propranolol - pharmacology; Rats; Receptors, Adrenergic, alpha - drug effects; Receptors, Adrenergic, alpha - physiology; Ventricular Function; Vertebrates: cardiovascular system; Heart; Vertebrata; Mammalia; Rat; α-Adrenergic receptor; Rodentia; Electrophysiology; Norepinephrine; Adrenergic receptor; Outward current; Voltage clamp method; Myocyte

The effects of alpha adrenoceptor stimulation with noradrenaline were investigated in rat ventricular myocytes after blockade of beta receptors with propranolol (1 microM). At room temperature and low stimulation frequency (0.5 Hz), noradrenaline evoked a phentolamine-sensitive increase in contracti...