The kappa opioid agonist U-50,488H antagonizes respiratory effects of mu opioid receptor agonists in conscious rats

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 264; no. 2; pp. 631 - 637
• Main Authors: DOSAKA-AKITA, K, TORTELLA, F. C, HOLADAY, J. W, LONG, J. B
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Pharmacology and Experimental Therapeutics 01.02.1993
• Subjects: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics - pharmacology; Animals; Biological and medical sciences; Enkephalin, Ala-MePhe-Gly; Enkephalins - antagonists & inhibitors; Male; Medical sciences; Morphine - antagonists & inhibitors; Naltrexone - analogs & derivatives; Naltrexone - pharmacology; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems; Pharmacology. Drug treatments; Pyrrolidines - pharmacology; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa - drug effects; Receptors, Opioid, mu - drug effects; Respiration - drug effects; Agonist; Rat; Respiratory disease; Rodentia; Morphine; Opiates; Respiratory system; Opioid peptide; Opiate receptor μ; Opiate receptor κ; Vertebrata; Antagonism; Mammalia; Animal; Intracerebral administration; Drug interaction; Respiratory depression; Respiration; Brain (vertebrata)

The interactive effects of mu and kappa opioid receptor agonists on respiratory function were investigated following their i.c.v. injection into conscious rats. The highly selective mu receptor agonist [D-Ala2,N-Methyl-Phe4,Gly-ol] enkephalin (DAMGO; 1.2-10 nmol) and the relatively selective mu agon...