Cytochrome P450 2B isoenzymes are responsible for the pulmonary bioactivation and toxicity of butylated hydroxytoluene, O,O,S-trimethylphosphorothioate and methylcyclopentadienyl manganese tricarbonyl

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 266; no. 2; pp. 958 - 963
• Main Authors: VERSCHOYLE, R. D, WOLF, C. R, DINSDALE, D
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Pharmacology and Experimental Therapeutics 01.08.1993
• Subjects: Animals; Biological and medical sciences; Biotransformation; Butylated Hydroxytoluene - pharmacokinetics; Butylated Hydroxytoluene - toxicity; Chemical and industrial products toxicology. Toxic occupational diseases; Cytochrome P-450 Enzyme System - physiology; Female; Glutathione - physiology; Isoenzymes - physiology; Lung - drug effects; Medical sciences; Organometallic Compounds - pharmacokinetics; Organometallic Compounds - toxicity; Organothiophosphates - pharmacokinetics; Organothiophosphates - toxicity; Rats; Rats, Wistar; Solvents; Toxicology; Rat; Isozyme; Toxicity; Cytochrome P450; Lung; Rodentia; Respiratory system; Organic solvent; Vertebrata; Mammalia; Mouse; Animal; Metabolic activation; Toluene derivatives; Mechanism of action

O,O,S-Trimethylphosphorothioate and methylcyclopentadienyl manganese tricarbonyl damage the type I pneumocytes of the alveolar epithelium in rats. Butylated hydroxytoluene causes similar damage in mice. The toxicity of these compounds is dependent on their bioactivation by the cytochrome P-450 (CYP)...