A Mathematical Model for the Distribution of Fluorodeoxyglucose in Humans

• Published in: The Journal of nuclear medicine (1978) Vol. 40; no. 8; pp. 1358 - 1366
• Main Authors: Hays, Marguerite T, Segall, George M
• Format: Journal Article
• Language: English
• Published: Reston, VA Soc Nuclear Med 01.08.1999; Society of Nuclear Medicine
• Subjects: Adult; Biological and medical sciences; Computerized, statistical medical data processing and models in biomedicine; Contrast media. Radiopharmaceuticals; Female; Fluorodeoxyglucose F18 - pharmacokinetics; Heart - diagnostic imaging; Humans; Lung - diagnostic imaging; Male; Medical sciences; Models and simulation; Models, Biological; Models, Theoretical; Myocardium - metabolism; Pharmacology. Drug treatments; Reference Values; Tissue Distribution; Tomography, Emission-Computed; Urinary Bladder - diagnostic imaging; Urinary Bladder - metabolism; Radionuclide study; Human; Biomedical data processing; Radiolabelling; Fluorine; Bioavailability; Glucose; Mathematical model; Pharmacokinetics; Radiopharmaceuticals; Biomedical engineering

The goals of this study were to define the total body distribution kinetics of 18F-fluorodeoxyglucose (FDG), to contribute to its radiation dosimetry and to define a suitable proxy for arterial cannulation in human FDG studies. Time-activity FDG heart, lung, liver and blood data from paired fasting...