Comparison of Myocardial Imaging with Iodine-123-Iodophenyl-9-Methyl Pentadecanoic Acid and Thallium-201-Chloride for Assessment of Patients with Exercise-Induced Myocardial Ischemia

• Published in: The Journal of nuclear medicine (1978) Vol. 32; no. 3; pp. 447 - 452
• Main Authors: Chouraqui, Pierre, Maddahi, Jamshid, Henkin, Robert, Karesh, Stephen M, Galie, Elizabeth, Berman, Daniel S
• Format: Journal Article
• Language: English
• Published: Reston, VA Soc Nuclear Med 01.03.1991; Society of Nuclear Medicine
• Subjects: 550601 - Medicine- Unsealed Radionuclides in Diagnostics; Aged; BETA DECAY RADIOISOTOPES; Biological and medical sciences; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COMPARATIVE EVALUATIONS; Coronary Disease - diagnostic imaging; Coronary Disease - etiology; DAYS LIVING RADIOISOTOPES; DIAGNOSIS; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EXERCISE; Exercise Test; Fatty Acids; Female; HEART; Heart - diagnostic imaging; HEAVY NUCLEI; HOURS LIVING RADIOISOTOPES; Humans; IMAGE PROCESSING; INTERMEDIATE MASS NUCLEI; Investigative techniques, diagnostic techniques (general aspects); IODINE 123; IODINE ISOTOPES; Iodobenzenes; ISCHEMIA; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; LUNGS; Male; Medical sciences; Middle Aged; MUSCLES; MYOCARDIUM; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PATIENTS; PROCESSING; RADIOISOTOPES; RADIOLOGY AND NUCLEAR MEDICINE; Radionuclide Imaging; RADIOPHARMACEUTICALS; RESPIRATORY SYSTEM; SECONDS LIVING RADIOISOTOPES; Thallium; THALLIUM 201; THALLIUM ISOTOPES; Thallium Radioisotopes; VASCULAR DISEASES; Thallium; Ischemia; Myocardium; Cardiovascular disease; Medical imagery; Radiopharmaceuticals; Iodine
• ISSN: 0161-5505

Iodine-123-iodophenyl-9-methyl-pentadecanoic acid [( 123I]MPDA) and thallium-201 (201Tl) were sequentially injected in 11 patients during exercise-induced myocardial ischemia. Simultaneous dual-energy planar images were obtained at 5 min, 3 and 5 hr. All studies were concordantly either positive (8/11) or negative (3/11) by both radionuclides. Exact agreement for segmental uptake was 93%, 94% and 94% for 5-min, 3- and 5-hr images, respectively. Exact agreement for defect reversibility by 3 and 5 hr were 95% and 92%. The initial defect contrasts and myocardial-to-lung ratios were similar by both agents but myocardial-to-liver ratio was lower by [123I]MPDA at 5 min, which became similar to 201Tl at 5 hr. Normal percent myocardial clearances of both agents were comparable and significantly higher than those in defect zones. Thus [123I]MPDA is suitable for myocardial imaging and correlates closely with 201Tl for initial postexercise myocardial uptake and defect reversibility. Defect reversibility appears to result from differential myocardial clearance from normal and ischemic regions.