Insulin-like Growth Factor I (IGF-I), IGF-binding Proteins, and Breast Cancer

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 11; no. 12; pp. 1566 - 1573
• Main Authors: KRAJCIK, Rozlyn A, BOROFSKY, Nancy D, MASSARDO, Stephen, ORENTREICH, Norman
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.12.2002
• Subjects: Adult; Age Distribution; Aged; Biological and medical sciences; Biomarkers - blood; Breast Neoplasms - epidemiology; Breast Neoplasms - etiology; Breast Neoplasms - physiopathology; Case-Control Studies; Cohort Studies; Female; Gynecology. Andrology. Obstetrics; Humans; Incidence; Insulin-Like Growth Factor Binding Proteins - adverse effects; Insulin-Like Growth Factor I - adverse effects; Logistic Models; Mammary gland diseases; Medical sciences; Middle Aged; Multivariate Analysis; Odds Ratio; Postmenopause; Premenopause; Prognosis; Reference Values; Risk Assessment; Risk Factors; Sensitivity and Specificity; Survival Analysis; Tumors; Human; Mammary gland diseases; Binding protein; Risk factor; Female; Mammary gland; Malignant tumor; Insulin like growth factor 1; Epidemiology

Epidemiological evidence supports a role for the insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) in the induction and progression of various cancers. Estrogen, which plays a role in the etiology of breast cancer, both regulates and is influenced by the IGF family. Risk of brea...