Segregation Analysis of 231 Ashkenazi Jewish Families for Evidence of Additional Breast Cancer Susceptibility Genes

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 12; no. 10; pp. 1045 - 1052
• Main Authors: KAUFMAN, David J, BEATY, Terri H, STRUEWING, Jeffery P
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.10.2003
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Breast Neoplasms - ethnology; Breast Neoplasms - genetics; DNA Mutational Analysis; Female; Genes, BRCA1; Genes, BRCA2; Genes, Recessive; Genetic Predisposition to Disease; Gynecology. Andrology. Obstetrics; Humans; Jews - genetics; Mammary gland diseases; Medical sciences; Middle Aged; Models, Genetic; Pedigree; Tumors; United States; North America; America; Human; Family study; Malignant tumor; Epidemiology; Ethnic group; Mammary gland diseases; Segregation analysis; Gene; Autosomal character; Risk factor; Genetics; Recessive character; Mammary gland; Jew; Public health

Between 5 and 10% of breast cancer is attributable to inherited cancer susceptibility genes. Mutations in the genes BRCA1 and BRCA2 account for two-thirds of hereditary breast cancer cases. Using segregation analysis, families of cases without BRCA1/2 mutations were studied for statistical evidence...