KIT activation is a ubiquitous feature of gastrointestinal stromal tumors

• Published in: Cancer research (Chicago, Ill.) Vol. 61; no. 22; pp. 8118 - 8121
• Main Authors: RUBIN, Brian P, SINGER, Samuel, DEMETRI, George D, FLETCHER, Christopher D. M, FLETCHER, Jonathan A, TSAO, Connie, DUENSING, Anette, LUX, Marcia L, RUIZ, Robert, HIBBARD, Michele K, CHEN, Chang-Jie, SHENG XIAO, TUVESON, David A
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.11.2001
• Subjects: Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Biological and medical sciences; DNA, Complementary - genetics; DNA, Neoplasm - genetics; Enzyme Activation; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gastrointestinal Neoplasms - enzymology; Gastrointestinal Neoplasms - genetics; Gastrointestinal Neoplasms - pathology; Humans; Immunohistochemistry; Male; Medical sciences; Middle Aged; Molecular Sequence Data; Mutation; Phosphorylation; Proto-Oncogene Proteins c-kit - biosynthesis; Proto-Oncogene Proteins c-kit - genetics; Proto-Oncogene Proteins c-kit - metabolism; Sequence Homology, Amino Acid; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Stromal Cells - enzymology; Stromal Cells - pathology; Tumors; Human; Nucleotide sequence; Enzyme; Pathogenesis; Transferases; Tumoral tissue; Stroma; Malignant tumor; Gene expression; Gastrointestinal; In vitro; Enzymatic activity; Protein kinase; DNA; Digestive diseases; Intestinal disease; Mutation; Gastric disease; Biological receptor

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, and they are generally resistant to chemotherapy and radiation therapy. Most GISTs express the KIT receptor tyrosine kinase protein, and a subset of GISTs contain activating mutations within...