Vitamin D Receptor Start Codon Polymorphism (FokI) and Prostate Cancer Progression

• Published in: Cancer epidemiology, biomarkers & prevention Vol. 12; no. 1; pp. 23 - 27
• Main Authors: YUE XU, SHIBATA, Atsuko, MCNEAL, John E, STAMEY, Thomas A, FELDMAN, David, PEEHL, Donna M
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.01.2003
• Subjects: Base Sequence; Biological and medical sciences; Codon, Initiator; Deoxyribonucleases, Type II Site-Specific - genetics; Genotype; Humans; Male; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Polymorphism, Genetic; Prognosis; Proportional Hazards Models; Prostatectomy; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Receptors, Calcitriol - genetics; Tumors of the urinary system; Urinary tract. Prostate gland; Adenocarcinoma; Histological grading; Human; Urinary system disease; Prognosis; Prostate disease; Male; Malignant tumor; Pathology; Phenotype; Vitamin D; Tumor progression; Cytogenetics; Molecular biology; Male genital diseases; Prostate; Polymorphism; Biological receptor

Vitamin D plays an important role in cell growth and differentiation and is proposed to protect against cancer initiation and/or progression. The vitamin D receptor (VDR) has a thymine/cytosine (T/C) polymorphism located in the first of two potential start (ATG) codons that can be detected by a RFLP...