Clinical and Molecular Responses in High-Grade Intraepithelial Neoplasia Treated with Topical Imiquimod 5

• Published in: Clinical cancer research Vol. 7; no. 10; pp. 3031 - 3033
• Main Authors: DIAZ-ARRASTIA, Concepcion, ARANY, Istvan, ROBAZETTI, Sonia C, DINH, Tung V, GATALICA, Zoran, TYRING, Stephen K, HANNIGAN, Edward
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.10.2001
• Subjects: 2',5'-Oligoadenylate Synthetase - genetics; Administration, Topical; Adult; Aminoquinolines - therapeutic use; Antineoplastic agents; Antineoplastic Agents - therapeutic use; Biological and medical sciences; Cervical Intraepithelial Neoplasia - drug therapy; Cervical Intraepithelial Neoplasia - genetics; Chemotherapy; Female; Follow-Up Studies; Gene Expression Regulation, Enzymologic - drug effects; Gene Expression Regulation, Neoplastic - drug effects; Genital Neoplasms, Female - drug therapy; Humans; Medical sciences; Middle Aged; Ointments; Pharmacology. Drug treatments; RNA, Neoplasm - genetics; RNA, Neoplasm - metabolism; Time Factors; Treatment Outcome; Uterine Cervical Neoplasms - drug therapy; Uterine Cervical Neoplasms - genetics; Vaginal Neoplasms - drug therapy; Vaginal Neoplasms - genetics; Vulvar Neoplasms - drug therapy; Vulvar Neoplasms - genetics; Antineoplastic agent; Histological grading; Human; Recurrence; Immunostimulation; Immune response; Imiquimod; Toxicity; Treatment efficiency; Biological marker; Vagina; Vulva; Uterine cervix; Malignant tumor; Epithelium; Female genital diseases; Percutaneous route; Chemotherapy; Treatment; Uterine cervix diseases; Topical administration

Objective: To assess the clinical and molecular response of patients with recurrent high-grade vulvar, vaginal, or cervical intraepithelial neoplasia treated with topical 1–2(2-methylpropyl)-1 H -imidazo [4,5- c ] quinolin-4-amine (imiquimod) cream 5%, an immune response modifier with known efficacy...