Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue

• Published in: Cancer research (Baltimore) Vol. 51; no. 18; pp. 4845 - 4852
• Main Authors: BISSERY, M.-C, GUENARD, D, GUERITTE-VOEGELEIN, F, LAVELLE, F
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.09.1991
• Subjects: Adenocarcinoma - drug therapy; Adenocarcinoma - pathology; Alkaloids - pharmacology; Alkaloids - toxicity; Animals; Antineoplastic agents; Antineoplastic Agents, Phytogenic - pharmacology; Antineoplastic Agents, Phytogenic - toxicity; Biological and medical sciences; Carcinoma, Intraductal, Noninfiltrating - drug therapy; Carcinoma, Intraductal, Noninfiltrating - pathology; Chemotherapy; Colonic Neoplasms - drug therapy; Colonic Neoplasms - pathology; Female; Leukemia, Experimental - drug therapy; Leukemia, Experimental - pathology; Lung Neoplasms - drug therapy; Lung Neoplasms - pathology; Male; Mammary Neoplasms, Experimental - drug therapy; Mammary Neoplasms, Experimental - pathology; Medical sciences; Melanoma, Experimental - drug therapy; Melanoma, Experimental - pathology; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental - drug therapy; Neoplasms, Experimental - pathology; Osteosarcoma - drug therapy; Osteosarcoma - pathology; Paclitaxel; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - pathology; Pharmacology. Drug treatments; Sarcoma, Experimental - drug therapy; Sarcoma, Experimental - pathology; Taxoids; Antineoplastic agent; Intraperitoneal administration; Intravenous administration; Treatment efficiency; Rodentia; Malignant tumor; Route of administration; Biological activity; Vertebrata; Chemotherapy; Mammalia; Treatment; Mouse; Analog; Animal

Taxotere (RP 56976; NSC 628503; N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl taxol) is a new microtubule stabilizing agent. It is obtained by semisynthesis from a noncytotoxic precursor extracted from the needles of the tree, Taxus baccata L. Taxotere was evaluated for antitumor activity against a...