Light-induced photoactivation of hypericin affects the energy metabolism of human glioma cells by inhibiting hexokinase bound to mitochondria - MICCOLI, L; BEURDELEY-THOMAS, A; DE PINIEUX, G; SUREAU, F; OUDARD, S; DUTRILLAUX, B; POUPON, M.-F (Cancer research (Chicago, Ill.), 1998)
Keywords: Apoptosis - drug effects; Biological and medical sciences; Energy Metabolism; Enzyme Inhibitors - pharmacology; Glioma - drug therapy; Glioma - metabolism; Hexokinase - antagonists & inhibitors; Hexokinase - metabolism; Humans; Hydrogen-Ion Concentration; Light; Medical sciences; Mitochondria - drug effects; Mitochondria - metabolism; Perylene - analogs & derivatives; Perylene - metabolism; Perylene - pharmacology; Photoradiation therapy and photosensitizing agent; Radiation-Sensitizing Agents - pharmacology; Thymidine - metabolism; Treatment with physical agents; Treatment. General aspects; Tumor Cells, Cultured; Tumors; Oxidative stress; Energy metabolism; Gene product; Cytotoxicity; Malignant glioma; Mitochondria; Ligases; Established cell line; pH; Mechanism of action; Tumor cell; Glutathione; Glutamate-cysteine ligase; Human; Nervous system diseases; Carbon-nitrogen ligases; Enzyme; Transferases; Enzyme inhibitor; Malignant tumor; Gene expression; In vitro; Hexokinase; Central nervous system disease; Photosensitizer; Apoptosis