Clinicopathological Features of Perforated Colorectal Cancer
The aim of this retrospective study was to determine clinicopathological factors pertinent to the prognosis of perforated colorectal cancer (PCRC). Patients and Methods: A retrospective review of clinical records of 17 cases of emergency primary resection for PCRC (stage IIIa in 2, stage IIIb in 6 a...
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Published in | Anticancer research Vol. 29; no. 5; pp. 1681 - 1684 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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International Institute of Anticancer Research
01.05.2009
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Abstract | The aim of this retrospective study was to determine clinicopathological factors pertinent to the prognosis of perforated
colorectal cancer (PCRC). Patients and Methods: A retrospective review of clinical records of 17 cases of emergency primary
resection for PCRC (stage IIIa in 2, stage IIIb in 6 and stage IV in 9) was perfomed. Result: The 5-year survival rate was
31% (31% for stage III and 12% for stage IV). When compared with non-PCRC (533 cases) in stage III (78.8%) or stage IV (14.8%),
the 5-year survival rate of stage III perforated colorectal cancer was clearly worse (p<0.01) than the non-perforated counterpart.
For stage IV, however, the two groups had a similar prognosis. MST of the PCRC was 31 months for stage III and 12 months for
stage IV. Approximately half of the recurrence pattern of stage III (75%), or stage IV (44%) PCRC was peritoneal carcinomatosis.
As for the type of operations performed, Hartmann's procedure was the preferred technique (71%), for which mortality and morbidity
rate were both low. Conclusion: Because of the high incidence of peritoneal carcinomatosis and low 5-year survival rate, stage
III PCRC should be regarded as a stage IV disease, for which postoperative chemotherapy seems essential. |
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AbstractList | The aim of this retrospective study was to determine clinicopathological factors pertinent to the prognosis of perforated
colorectal cancer (PCRC). Patients and Methods: A retrospective review of clinical records of 17 cases of emergency primary
resection for PCRC (stage IIIa in 2, stage IIIb in 6 and stage IV in 9) was perfomed. Result: The 5-year survival rate was
31% (31% for stage III and 12% for stage IV). When compared with non-PCRC (533 cases) in stage III (78.8%) or stage IV (14.8%),
the 5-year survival rate of stage III perforated colorectal cancer was clearly worse (p<0.01) than the non-perforated counterpart.
For stage IV, however, the two groups had a similar prognosis. MST of the PCRC was 31 months for stage III and 12 months for
stage IV. Approximately half of the recurrence pattern of stage III (75%), or stage IV (44%) PCRC was peritoneal carcinomatosis.
As for the type of operations performed, Hartmann's procedure was the preferred technique (71%), for which mortality and morbidity
rate were both low. Conclusion: Because of the high incidence of peritoneal carcinomatosis and low 5-year survival rate, stage
III PCRC should be regarded as a stage IV disease, for which postoperative chemotherapy seems essential. The aim of this retrospective study was to determine clinicopathological factors pertinent to the prognosis of perforated colorectal cancer (PCRC). A retrospective review of clinical records of 17 cases of emergency primary resection for PCRC (stage IIIa in 2, stage IIIb in 6 and stage IV in 9) was performed. The 5-year survival rate was 31% (31% for stage III and 12% for stage IV). When compared with non-PCRC (533 cases) in stage III (78.8%) or stage IV (14.8%), the 5-year survival rate of stage III perforated colorectal cancer was clearly worse (p<0.01) than the non-perforated counterpart. For stage IV, however, the two groups had a similar prognosis. MST of the PCRC was 31 months for stage III and 12 months for stage IV. Approximately half of the recurrence pattern of stage III (75%), or stage IV (44%) PCRC was peritoneal carcinomatosis. As for the type of operations performed, Hartmann's procedure was the preferred technique (71%), for which mortality and morbidity rate were both low. Because of the high incidence of peritoneal carcinomatosis and low 5-year survival rate, stage III PCRC should be regarded as a stage IV disease, for which postoperative chemotherapy seems essential. UNLABELLEDThe aim of this retrospective study was to determine clinicopathological factors pertinent to the prognosis of perforated colorectal cancer (PCRC).PATIENTS AND METHODSA retrospective review of clinical records of 17 cases of emergency primary resection for PCRC (stage IIIa in 2, stage IIIb in 6 and stage IV in 9) was performed.RESULTThe 5-year survival rate was 31% (31% for stage III and 12% for stage IV). When compared with non-PCRC (533 cases) in stage III (78.8%) or stage IV (14.8%), the 5-year survival rate of stage III perforated colorectal cancer was clearly worse (p<0.01) than the non-perforated counterpart. For stage IV, however, the two groups had a similar prognosis. MST of the PCRC was 31 months for stage III and 12 months for stage IV. Approximately half of the recurrence pattern of stage III (75%), or stage IV (44%) PCRC was peritoneal carcinomatosis. As for the type of operations performed, Hartmann's procedure was the preferred technique (71%), for which mortality and morbidity rate were both low.CONCLUSIONBecause of the high incidence of peritoneal carcinomatosis and low 5-year survival rate, stage III PCRC should be regarded as a stage IV disease, for which postoperative chemotherapy seems essential. |
Author | KEN HANYU LOHTA NOAKI MAKOTO KOSUGE TETSUJI FUJITA KEN ETO MICHIAKI WATANABE TAKAHIRO OMACHI KATSUHIKO YANAGA MASAICHI OGAWA |
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Keywords | Colonic disease Rectal disease Cancerology Clinico-pathological features Hartmann's procedure Perforation Colorectal cancer Digestive diseases Intestinal disease Malignant tumor Cancer |
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Snippet | The aim of this retrospective study was to determine clinicopathological factors pertinent to the prognosis of perforated
colorectal cancer (PCRC). Patients... The aim of this retrospective study was to determine clinicopathological factors pertinent to the prognosis of perforated colorectal cancer (PCRC). A... UNLABELLEDThe aim of this retrospective study was to determine clinicopathological factors pertinent to the prognosis of perforated colorectal cancer... |
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SubjectTerms | Biological and medical sciences Colorectal Neoplasms - pathology Gastroenterology. Liver. Pancreas. Abdomen Humans Medical sciences Retrospective Studies Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
Title | Clinicopathological Features of Perforated Colorectal Cancer |
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