Effect of sodium butyrate and other differentiation inducers on poorly differentiated human ovarian adenocarcinoma cell lines

• Published in: Cancer research (Chicago, Ill.) Vol. 48; no. 21; pp. 6161 - 6165
• Main Authors: LANGDON, S. P, HAWKES, M. M, HAY, F. G, LAWRIE, S. S, SCHOL, D. J, HILGERS, J, LEONARD, R. C. F, SMYTH, J. F
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.11.1988
• Subjects: Adenocarcinoma - immunology; Adenocarcinoma - pathology; Alkaline Phosphatase - analysis; Antigens, Neoplasm - analysis; Antineoplastic agents; Biological and medical sciences; Butyrates - pharmacology; Butyric Acid; Cell Differentiation - drug effects; Dimethyl Sulfoxide - pharmacology; DNA, Neoplasm - biosynthesis; Fatty Acids - pharmacology; Female; General aspects; Humans; Medical sciences; Ovarian Neoplasms - immunology; Ovarian Neoplasms - pathology; Pharmacology. Drug treatments; Tretinoin - pharmacology; Tumor Cells, Cultured; Alkaline phosphatase; Cell culture; Ovary; Cell line; Antigenic determinant; Biological marker; Cell differentiation; Inductor; Retinoic acid; Tumor cell

We have studied the effects of sodium butyrate, retinoic acid, and dimethyl sulfoxide on two human ovarian carcinoma cell lines PE04 and PE01. PE04 cells, after treatment with sodium butyrate at cytostatic doses (2-3 mM for 4 days), exhibited phenotypic changes including induction of alkaline phosph...