Increased expression of neutrophil and monocyte adhesion molecules LFA-1 and Mac-1 and their ligand ICAM-1 and VLA-4 throughout the acute phase of myocardial infarction possible implications for leukocyte aggregation and microvascular plugging

• Published in: Journal of the American College of Cardiology Vol. 31; no. 1; pp. 120 - 125
• Main Authors: MEISEL, S. R, SHAPIRO, H, RADNAY, J, NEUMAN, Y, KHASKIA, A.-R, GRUENER, N, PAUZNER, H, DAVID, D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Science 1998
• Subjects: Aged; Biological and medical sciences; Cardiology. Vascular system; Coronary heart disease; Female; Flow Cytometry; Heart; Humans; Integrin alpha4beta1; Integrins - blood; Intercellular Adhesion Molecule-1 - blood; Lymphocyte Function-Associated Antigen-1 - blood; Macrophage-1 Antigen - blood; Male; Medical sciences; Middle Aged; Myocardial Infarction - drug therapy; Myocardial Infarction - immunology; Neutrophil Activation; Receptors, Lymphocyte Homing - blood; Receptors, Very Late Antigen - blood; Thrombolytic Therapy; Human; Flow cytometry; Infarct; Monocyte; Intercellular adhesion molecule-1; Myocardium; Cardiovascular disease; Exploration; Neutrophil; Gene expression; Coronary heart disease

This study sought to evaluate expression of adhesion molecules on neutrophils and monocytes throughout the acute phase of myocardial infarction. Neutrophil and monocyte counts increase within days from onset of acute myocardial infarction. Because leukocytes are recruited to the involved myocardial...