Loss of heterozygosity on chromosome 13 is common only in the biologically more aggressive subtypes of ovarian epithelial tumors and is associated with normal retinoblastoma gene expression

• Published in: Cancer research (Chicago, Ill.) Vol. 54; no. 3; pp. 605 - 609
• Main Authors: Kim, T M, Benedict, W F, Xu, H J, Hu, S X, Gosewehr, J, Velicescu, M, Yin, E, Zheng, J, D'Ablaing, G, Dubeau, L
• Format: Journal Article
• Language: English
• Published: United States 01.02.1994
• Subjects: Alleles; Base Sequence; Carcinoma - genetics; Chromosomes, Human, Pair 13 - physiology; Cystadenoma - genetics; Epithelium - pathology; Female; Gene Deletion; Gene Expression - genetics; Genes, Retinoblastoma - genetics; Heterozygote; Humans; Immunohistochemistry; Molecular Sequence Data; Ovarian Neoplasms - chemistry; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; Retinoblastoma Protein - analysis; Retinoblastoma Protein - genetics

We examined the frequencies of loss of heterozygosity on chromosome 13 in 77 primary ovarian epithelial tumors subdivided into cystadenomas, tumors of low malignant potential, low grade carcinomas, and high grade carcinomas. Such losses were found in approximately 50% of high grade carcinomas but we...