Alterations of microsatellites in neurofibromas of von Recklinghausen's disease

• Published in: Cancer research (Chicago, Ill.) Vol. 55; no. 23; pp. 5677 - 5680
• Main Authors: OTTINI, L, ESPOSITO, D. L, CAMA, A, MARIANI-COSTANTINI, R, RICHETTA, A, CARLESIMO, M, PALMIROTTA, R, VERI, M. C, BATTISTA, P, FRATI, L, CARAMIA, F. G, CALVIERI, S
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.12.1995
• Subjects: Adult; Aged; Biological and medical sciences; Chromosome Deletion; DNA, Neoplasm - genetics; DNA, Satellite - genetics; Female; Genes, Neurofibromatosis 1 - genetics; Genetic Markers; Humans; Male; Medical sciences; Middle Aged; Neurofibromatosis 1 - genetics; Neurology; Skin Neoplasms - genetics; Tumors of the nervous system. Phacomatoses; Human; Tissue; Skin disease; Nervous system diseases; Phacomatosis; Pathogenesis; Microsatellite DNA; Instability; Benign neoplasm; Mutation; Neurofibromatosis Recklinghausen; Genetic disease

von Recklinghausen's disease, or type I neurofibromatosis, a common familial tumor syndrome, is characterized by the occurrence of multiple benign neoplasms of nerve sheath cells. The disease is caused by germ-line mutations of the NF1 gene, which encodes a member of the GTPase-activating super...