Immunological approaches to the purification of putative premalignant hepatocytes from genotypic mosaic rat livers

• Published in: Cancer research (Chicago, Ill.) Vol. 45; no. 5; pp. 2226 - 2233
• Main Authors: HUNT, J. M, BUCKLEY, M. T, LAISHES, B. A, DUNSFORD, H. A
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.05.1985
• Subjects: Animal tumors. Experimental tumors; Animals; Biological and medical sciences; Cell Separation - methods; Experimental digestive system and abdominal tumors; Fluorescent Antibody Technique; gamma-Glutamyltransferase - analysis; Isoantigens - analysis; Liver - enzymology; Liver Neoplasms, Experimental - immunology; Liver Neoplasms, Experimental - pathology; Liver Transplantation; Medical sciences; Mosaicism; Neoplasm Transplantation; Precancerous Conditions - immunology; Precancerous Conditions - pathology; Rats; Rats, Inbred F344; Tumors; Vertebrata; Mammalia; Premalignant lesion; Rat; Liver; Rodentia; Genotype; Mosaicism; Experimental tumor

Surface-localized rat RT1 alloantigens on isolated hepatocytes have been used to achieve partial purification of putative premalignant liver cells from rats undergoing chemically induced hepatocarcinogenesis. Genotypic mosaic rat livers were constructed by transplantation of carcinogen-altered F-344...