Up- and down-regulation of granulocyte/macrophage-colony stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms

• Published in: Cancer research (Chicago, Ill.) Vol. 61; no. 5; pp. 2311 - 2319
• Main Authors: MANN, Amrit, BREUHAHN, Kai, SCHIRMACHER, Peter, WILHELMI, Arnd, BEYER, Carsten, ROSENAU, Andrea, ÖZBEK, Suat, ROSE-JOHN, Stefan, BLESSING, Manfred
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.03.2001
• Subjects: 9,10-Dimethyl-1,2-benzanthracene; Animals; Biological and medical sciences; Carcinogens; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Down-Regulation; Fundamental and applied biological sciences. Psychology; Granulocyte-Macrophage Colony-Stimulating Factor - antagonists & inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis; Granulocyte-Macrophage Colony-Stimulating Factor - genetics; Granulocyte-Macrophage Colony-Stimulating Factor - physiology; Keratin-10; Keratins - genetics; Melanoma, Experimental - genetics; Melanoma, Experimental - pathology; Mice; Mice, Transgenic; Molecular and cellular biology; Neoplasm Transplantation; Phenotype; Skin - metabolism; Skin Neoplasms - chemically induced; Skin Neoplasms - etiology; Skin Neoplasms - genetics; Skin Neoplasms - metabolism; Skin Physiological Phenomena - drug effects; Skin Physiological Phenomena - genetics; Tetradecanoylphorbol Acetate; Transgenes; Up-Regulation; Cell proliferation; Gene product; Rodentia; Cytokine; Transgenic animal; Gene overexpression; Epidermis; Malignant tumor; Gene expression; Carcinogenesis; Vertebrata; Mammalia; Sensitivity resistance; Mouse; Cell death; Animal; Skin; Antagonist; Mechanism of action; Tumor promotion; Granulocyte macrophage colony stimulating factor; Apoptosis

The role of granulocyte-macrophage colony-stimulating factor (GM-CSF) in tumorigenesis is complex. On the one hand, GM-CSF can promote tumor cell growth, survival, and even metastasis. On the other hand, it can stimulate tumor cell rejection. In skin, it is early expressed after topic application of...