Control of Expression of Major Histocompatibility Complex Genes in Horse Trophoblast

• Published in: Biology of reproduction Vol. 66; no. 6; pp. 1612 - 1620
• Main Authors: BACON, S. J, ELLIS, S. A, ANTCZAK, D. F
• Format: Journal Article
• Language: English
• Published: Madison, WI Society for the Study of Reproduction 01.06.2002
• Subjects: Allantois - metabolism; Animals; beta 2-Microglobulin; Biological and medical sciences; Chorion - metabolism; Embryology: invertebrates and vertebrates. Teratology; Female; Fetal membranes; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; General aspects. Development. Fetal membranes; Histocompatibility Antigens Class I - genetics; Histocompatibility Antigens Class II - genetics; Horses - embryology; Immunohistochemistry; Organ Specificity; Pregnancy; Transcription, Genetic; Trophoblasts - metabolism; Trophoblaste; Vertebrata; Mammalia; Fetal membrane; Major histocompatibility system; Horse; Perissodactyla; Gene expression; Ungulata

In most mammals, the fetus limits its presentation of paternal antigens to the mother by suppressing the cell-surface expression of proteins of the major histocompatibility complex (MHC) on trophoblast. In the horse, however, functional, polymorphic MHC class I antigens are expressed at high levels...