Aspirin use and risk of fatal cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 53; no. 6; pp. 1322 - 1327
• Main Authors: THUN, M. J, NAMBOODIRI, M. M, CALLE, E. E, FLANDERS, W. D, HEALTH, C. W
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.03.1993
• Subjects: Acetaminophen - therapeutic use; Aspirin - therapeutic use; Biological and medical sciences; Colonic Neoplasms - mortality; Colonic Neoplasms - prevention & control; Digestive System Neoplasms - mortality; Digestive System Neoplasms - prevention & control; Esophageal Neoplasms - mortality; Esophageal Neoplasms - prevention & control; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Male; Medical sciences; Middle Aged; Multivariate Analysis; Prospective Studies; Rectal Neoplasms - mortality; Rectal Neoplasms - prevention & control; Risk; Stomach Neoplasms - mortality; Stomach Neoplasms - prevention & control; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; United States; North America; America; Non steroidal antiinflammatory agent; Human; Prevention; Stomach; Treatment; Digestive diseases; Colon; Malignant tumor; Anticarcinogen; Epidemiology; Public health

Aspirin and other nonsteroidal antiinflammatory drugs inhibit prostaglandin synthesis and tumor growth in many experimental systems, but it is unclear which of these tumor models are relevant to humans. We have reported reduced risk of fatal colon cancer among persons who used aspirin in a large pro...