Flavopiridol Increases Sensitization to Gemcitabine in Human Gastrointestinal Cancer Cell Lines and Correlates with Down-Regulation of Ribonucleotide Reductase M2 Subunit - JUNG, Christoph P; MOTWANI, Monica V; SCHWARTZ, Gary K (Clinical cancer research, 2001)
Keywords: Antineoplastic agents; Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Biological and medical sciences; Blotting, Western; Cell Cycle Proteins - drug effects; Cell Cycle Proteins - metabolism; Chemotherapy; Cyclin D1 - drug effects; Cyclin D1 - metabolism; Cyclin E - drug effects; Cyclin E - metabolism; Cysteine Endopeptidases - drug effects; Cysteine Endopeptidases - metabolism; Cytochrome c Group - drug effects; Cytochrome c Group - secretion; Deoxycytidine - analogs & derivatives; Deoxycytidine - pharmacology; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Inhibitors - pharmacology; Flavonoids - pharmacology; Gastrointestinal Neoplasms - drug therapy; Gastrointestinal Neoplasms - enzymology; Gastrointestinal Neoplasms - pathology; Gene Expression Regulation, Enzymologic - drug effects; Humans; Medical sciences; Mitochondria - drug effects; Mitochondria - metabolism; Multienzyme Complexes - drug effects; Multienzyme Complexes - metabolism; Pharmacology. Drug treatments; Phosphorylation - drug effects; Piperidines - pharmacology; Poly(ADP-ribose) Polymerases - metabolism; Proteasome Endopeptidase Complex; Protein Subunits; Retinoblastoma Protein - drug effects; Retinoblastoma Protein - metabolism; Ribonucleotide Reductases - antagonists & inhibitors; Ribonucleotide Reductases - genetics; Ribonucleotide Reductases - metabolism; RNA, Messenger - drug effects; RNA, Messenger - genetics; RNA, Messenger - metabolism; Thymidine - metabolism; Transcription Factors - drug effects; Transcription Factors - metabolism; Tritium; Tumor Cells, Cultured; Tumor Stem Cell Assay; Antineoplastic agent; Potentiation; Catalytic subunit; Gemcitabine; Gene product; DNA synthesis; Gastrointestinal; Cell cycle; Established cell line; Intestinal disease; Mechanism of action; Pyrimidine nucleoside; Tumor cell; Gastric disease; Human; Stomach; Drug combination; Enzyme; Transferases; Gut; Enzyme inhibitor; Malignant tumor; Gene expression; In vitro; Biological activity; Sensitivity resistance; Cell death; Protein kinase; Digestive diseases; Fluorine Organic compounds; Apoptosis