Cytochrome P450 Down-Regulation by Serum from Humans with a Viral Infection and from Rabbits with an Inflammatory Reaction

• Published in: Drug metabolism and disposition Vol. 29; no. 7; pp. 1007 - 1012
• Main Authors: BLEAU, Anne-Marie, FRADETTE, Caroline, EL-KADI, Ayman O. S, COTE, Marie-Claude, DU SOUICH, Patrick
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Pharmacology and Experimental Therapeutics 01.07.2001
• Subjects: Analytical, structural and metabolic biochemistry; Animals; Biological and medical sciences; Blood; Cytochrome P-450 Enzyme System - metabolism; Down-Regulation; Enzymes and enzyme inhibitors; Fundamental and applied biological sciences. Psychology; Humans; Inflammation - blood; Inflammation - enzymology; Male; Oxidoreductases; Rabbits; Respiratory Tract Infections - blood; Respiratory Tract Infections - enzymology; Virus Diseases - blood; Virus Diseases - enzymology; Human; Digestive system; Isozyme; Cytochrome P450; Liver; Rabbit; Inflammation; Lagomorpha; In vitro; Infection; Vertebrata; Mammalia; Enzymatic activity; Hepatocyte; Animal; Viral disease; Serum

Serum from humans with an upper respiratory viral infection (HS URVI ) and from rabbits with a turpentine-induced acute inflammatory reaction (RS TIAR ) reduces the activity of hepatic cytochrome P450 (P450) following 4 h of incubation. The aim of the present study was to assess the effect of HS URV...